An assessment by the BlueCross BlueShield Association Technology Evaluation Center (BCBSA, 2014) stated: "The choice of bone material for interbody fusion in [anterior cervical discectomy and fusion] ACDF has important clinical implications. Allograft bone has several drawbacks, including a minute (albeit unproven) risk of infectious disease transmission; possible immunological reaction to the allograft; and possible limited commercial availability of appropriate graft material. In contrast, the use of autograft bone in ACDF has potentially substantial morbidities at the harvest site, generally the iliac crest. These include moderate-to-severe, sometimes prolonged pain; deep infection; adjacent nerve and artery damage; and increased risk of stress fracture. Although there may be slight differences between autograft and allograft sources in the postoperative rate of union, clinical studies have demonstrated similar rates of postoperative fusion (90%–100%) and satisfactory outcomes for single-level, anterior-plated ACDF using either bone source. Thus, the choice of graft material involves a trade-off between the risks specific to autograft harvest versus those specific to use of allograft material."
The C-One (or C1 ) is the development of the American Jeri Ellsworth and the German Jens Schoenfeld ( Individual Computers ) from 2002 This is an FGPA-based C-64 clone, which is similarly to the Sprinter, capable of simulating more machines. For emulating these platforms, so called 'cores' must be loaded into the FGPA, from which two fitted onto the mainboard. The so-called FGPA extender card contains a new Altera Cyclone 3 FGPA , which is necessary for emulating the new machines (Amiga, Spectrum). The specification of the mainboard are quite standart nowadays. PS/2 mouse and keyboard, SVGA monitor, IDE and PCI ports, only the audio output is not placed at its standard place. The processor is 65c816 with approximately 20MHz speed. This one is 6502 compatible with 24 but memory addressing. Above this, any 8 bit CPUs can fitted onto the mainboard. Mains specs: 1GB SDRAM maximum, from which maximum 128MB for multimedia of course with DMA access. The system loads the cores from so-called boot-ROM from either CF-card or winchester. So PC data change is possible and easy. Above the IDE DMA port, there is a floppy interface too, and serial and parallel socket also. The PAL 48K ZX Spectrum core () was made by Alessandro Dorigatti on 2011 May 24. It also supports the ULA+ 64 colours mode beside the standart Speccy gfx mode. At present, .TAP files are supported, .TZXs are not. The Z80 processor is emulated by the T80 software core. The ULA emulation is based on Chris Smith's ULA book (see later). Although among Dorigatti's work this emulating the less precisely the original Spectrum, all test programs ran without any errors (of course, excepted the routines, which are indentifiyng the CPU). As the C-One mainboard does not contains SD-card socket, only two IDE-ports, the author does not planning its further development. Technical specifications CPU: 65c816@20MHz RAM: 16M-1GB ROM: 512K Video: 256x192, 15 colours; ULA+ 64 colours Sound: beeper emulated (8 ch. stereo DMA) Keyboard: PS/2 Joystick: Kempston FDD: ?? (reserved) others: VGA, audio in/out, Centronics, RS232, IDE DMA, PCI Frissítve: 2012. június 08.