The molecular basis of hereditary non-autoimmune hyperthyroidism was elucidated by detecting activating germline mutations in the TSH receptor in the family reported by Thomas et al. (51). Gain-of-function mutations are by definition dominant, and alteration of one allele is thus sufficient for generating the phenotype. Interestingly, the onset of hyperthyroidism may vary in carriers of the same mutation in a given kindred. Hence, other factors, for example genetic background and/or iodine intake, appear to modulate the phenotypic expression (97, 99, 100).
Whatever you do, don’t let yourself be hungry on the protocol. This is not necessary nor it is healthy or advisable and it makes sticking to the diet almost impossible. It’s not about willpower okay? The hormone in the right dose is supposed to make the diet fairly comfortable, to an extent. Of course we’re all going to have emotional and social reasons for wanting to eat- that’s not going to just go away so easily, but the physical aspect of eating 500 calories or less on the diet should be manageable and fairly easy when you have the right dose of hCG.