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Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review.

Mishra LC, Singh BB, Dagenais S.

Los Angeles College of Chiropractic (LACC), 16200 E Amber Valley Dr., Whittier, CA 90609-1166. lakshmimishra@

OBJECTIVE: The objective of this paper is to review the literature regarding Withania somnifera (ashwagandha, WS) a commonly used herb in Ayurvedic medicine. Specifically, the literature was reviewed for articles pertaining to chemical properties, therapeutic benefits, and toxicity. DESIGN: This review is in a narrative format and consists of all publications relevant to ashwagandha that were identified by the authors through a systematic search of major computerized medical databases; no statistical pooling of results or evaluation of the quality of the studies was performed due to the widely different methods employed by each study. RESULTS: Studies indicate ashwagandha possesses anti-inflammatory, antitumor, antistress, antioxidant, immunomodulatory, hemopoietic, and rejuvenating properties. It also appears to exert a positive influence on the endocrine, cardiopulmonary, and central nervous systems. The mechanisms of action for these properties are not fully understood. Toxicity studies reveal that ashwagandha appears to be a safe compound. CONCLUSION: Preliminary studies have found various constituents of ashwagandha exhibit a variety of therapeutic effects with little or no associated toxicity . These results are very encouraging and indicate this herb should be studied more extensively to confirm these results and reveal other potential therapeutic effects. Clinical trials using ashwagandha for a variety of conditions should also be conducted.

PMID: 10956379

MAOIs started off due to the serendipitous discovery that iproniazid was a potent MAO inhibitor (MAOI). [41] Originally intended for the treatment of tuberculosis, in 1952, iproniazid's antidepressant properties were discovered when researchers noted that the depressed patients given iproniazid experienced a relief of their depression. Subsequent in vitro work led to the discovery that it inhibited MAO and eventually to the monoamine theory of depression . MAOIs became widely used as antidepressants in the early 1950s. The discovery of the 2 isoenzymes of MAO has led to the development of selective MAOIs that may have a more favorable side-effect profile. [42]

Stone, Michael H. (1993). Abnormalities of personality: within and beyond the realm of treatment . New York: . Norton. Tamney, Joseph B. (2002). The Resilience of Conservative Religion . New York: Cambridge UP.

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  • Mental Health Net - Histrionic Personality Disorder Symptoms
  • Diagnostic Criteria for Histrionic Personality Disorder
  • Health Center: Personality Disorders: Histrionic
  • Dual Diagnosis and the Histrionic Personality Disorder
  • Histrionic Personality: Functional and Structural Domain Descriptions - Theodore Millon.
  • Histrionic Personality Disorder - Internet Mental Health.
  • Psych Central: Histrionic Personality Disorder Symptoms
  • Mental Health Net - Somatization Disorder Symptoms
  • Dissociative Identity Disorder: a contribution - Dr. John Hambling MD. "In this piece Dr. Hambling draws together the many factors acting in a sufferer's childhood to produce the 'typical' DID profile, illustrating these with graphic examples from his own work with children and adults. Among them the analysis singles out 'the mother who hates' as a major factor sparking the formation of self-protective fantasy identities by the child. These, of course, are the so-called 'multiple personalities' that give the condition the name by which it is more popularly known - multiple personality disorder, or MPD."
  • Fibromyalgia, Myofascial Pain Syndrome, Chronic Pain Syndrome, and Somatization Disorder - Is There a Connection?
  • "Debunking an Unscientific Hypothesis: Fibromyalgia is Not a Somatoform Disorder" [?]
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  • Conversion Disorder? - a post and the responses to the Neurology WebForum: Behavioral Disorders.
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  • Hysteria: a Clinical and Sociodemographic Profile of 40 Patients Admitted to a Teaching Hospital, 1985-1995
  • Histrionic Personality Disorder - "morphological and constitutional features in the hand."
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Ever since SSRIs were first created and marketed, clinicians have had to deal with the fallout of the occasional patient who not only didn’t respond correctly to the medication, but had intense, violent, and sometimes suicidal reactions to the drugs. In most cases, these problems were quickly resolved by stopping or altering the medication given. Suicide was uncommon in these cases, but there was no doubt that the drug did create an intense reaction in some younger patients. The presence of bipolar spectrum disorder in these individuals might indeed have been a contributing factor.

Hysteroid dysphoria symptoms

hysteroid dysphoria symptoms

Ever since SSRIs were first created and marketed, clinicians have had to deal with the fallout of the occasional patient who not only didn’t respond correctly to the medication, but had intense, violent, and sometimes suicidal reactions to the drugs. In most cases, these problems were quickly resolved by stopping or altering the medication given. Suicide was uncommon in these cases, but there was no doubt that the drug did create an intense reaction in some younger patients. The presence of bipolar spectrum disorder in these individuals might indeed have been a contributing factor.

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