Herpesviral Encephalitis can be treated with high-dose intravenous acyclovir . Without treatment, HSE results in rapid death in approximately 70% of cases; survivors suffer severe neurological damage.  When treated, HSE is still fatal in one-third of cases, and causes serious long-term neurological damage in over half of survivors. Twenty percent of treated patients recover with minor damage. Only a small population of survivors (%) regain completely normal brain function.  Indeed, many amnesic cases in the scientific literature have etiologies involving HSE. Earlier treatment (within 48 hours of symptom onset) improves the chances of a good recovery. Rarely, treated individuals can have relapse of infection weeks to months later. There is evidence that aberrant inflammation triggered by herpes simplex can result in granulomatous inflammation in the brain, which responds to steroids.  While the herpes virus can be spread, encephalitis itself is not infectious. Other viruses can cause similar symptoms of encephalitis, though usually milder ( Herpesvirus 6 , varicella zoster virus , Epstein-Barr , cytomegalovirus , coxsackievirus , etc.).
Shingles can be very painful and itchy. It is not very dangerous to healthy people, and it usually ends without major problems. The rash and pain last 3 to 5 weeks. Sometimes, serious problems like temporary, partial facial paralysis , ear damage, or encephalitis may occur. Persons with shingles on the upper half of the face need immediate medical attention: the virus may cause serious damage to the eyes . Most people who have shingles have only one attack of the disease in their lifetime. However, people with AIDS , cancer or weak immune systems may have multiple attacks.