As a glucocorticoid , the lipophilic structure of prednisolone allows for easy passage through the cell membrane where it then binds to its respective glucocorticoid receptor (GCR) located in the cytoplasm. Upon binding, formation of the GC/GCR complex causes dissociation of chaperone proteins from the glucocorticoid receptor enabling the GC/GCR complex to translocate inside the nucleus. This process occurs within 20 minutes of binding. Once inside the nucleus, the homodimer GC/GCR complex binds to specific DNA binding-sites known as glucocorticoid response elements (GREs) resulting in gene expression or inhibition. Complex binding to positive GREs leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes. 
I recently finished a series of lumbar cortisone shots for a back injury. The last shot produced some strange reactions. The day after, I awoke with heightened sensory perceptions. Objects were brighter, sounds louder, smells stronger, and thoughts clearer; very psychedelic. Then I began having rapid heartbeat, pulse and my blood pressure skyrocketed. I had profuse sweating . Now 5 days later, I am on the mend. I thought. However, a red, flat, itchy , painful rash appeared under my breasts streaking down my torso. I thought it might be heat rash . My previous injections had no side effects, indicating to me, personally, that this might be a cumulative effect.
Children who are on immunosuppressant drugs are more susceptible to infections than healthy children. Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. In such children, or in adults who have not had these diseases, particular care should be taken to avoid exposure. If exposed, therapy with varicella zoster immune globulin (VZIG) or pooled intravenous immunoglobulin (IVIG), as appropriate, may be indicated. If chicken pox develops, treatment with antiviral agents may be considered.